Endometriosia eta ezaugarri antropometriko eta menstrualak: oinarri genetiko komunaren bila

Endometriosia kausa ezezaguneko gaixotasun ginekologiko ohikoenetariko bat da, funtzionalki aktiboa den endometrio-ehuna umetoki-barrunbetik kanpo haztean agertzen dena. Fenotipo ugarirekin erlazionatu da, hala nola neurri antropometrikoekin eta ezaugarri menstrualekin. Hala ere, ez da oraindik ezagutzen azken horiek eta endometriosiak oinarri genetiko bera partekatzen duten. Genetika komun hori aztertzeko, bi lagineko ausazkotze mendeldarraren (2SMR) analisia egin genuen, GWAS ikerketetako datu publikoak erabiliz. Gure emaitzen arabera, pisu baxuak eta hilekoaren ziklo laburrek endometriosiarekin harreman genetikoa dute. Are gehiago, badirudi erlazio hori kausala izan litekeela. Gako-hitzak: Endometriosia, ausazkotze mendeldarra, ezaugarri antropometrikoak, ezaugarri menstrualak. Endometriosis and anthropometric and menstrual traits: searching for common genetic roots Endometriosis, of unknown cause, is one of the most prevalent gynecological diseases, characterized by the presence of functionally active endometrialt issue outside the womb. It has been associated with many phenotypes, such as anthropometric and menstrual traits. However, whether these traits and endometriosis share common genetic roots is still undetermined. To investigate this, we performed a two-sample Mendelian randomization (2SMR) analysis, using public data from GWAS studies. Our results showed a genetic link between low weight and shorts menstrual cyclesandendometriosis. Furthermore, it seems that this relationship could be causal. Keywords: Endometriosis, mendelianrandomization, anthropometrictraits, menstrual traits.